![]() Median peak CAR T-cell expansion was low (0.98 cells/μL), as were median peak serum levels of CAR-associated cytokines, including interferon-γ (61.45 pg/mL) and interleukin-2 (0.9 pg/mL). Among all patients infused with KITE-585, 1 patient who received 3 × 10 7 anti-BCMA CAR T cells experienced a partial response. There were no grade ≥ 3 events of cytokine release syndrome, neurologic events, or infections all were grade 1 or 2, and each occurred in 21.4% of patients. No patients experienced a DLT, all patients experienced ≥ 1 grade ≥ 3 treatment-emergent AE (TEAE), and no grade 5 TEAEs were observed. The median age of patients was 56 years, 41.2% had an Eastern Cooperative Oncology Group performance status of 1, 92.9% had baseline BCMA expression on plasma cells, and median number of prior therapies was 5.5. Seventeen patients were enrolled, and 14 received KITE-585 with a median follow-up of 12.0 months. Key secondary and exploratory endpoints included efficacy outcomes, incidence of AEs, levels of KITE-585 in blood, serum cytokines, and incidence of anti-BCMA CAR antibodies. The primary endpoint was incidence of adverse events (AEs) defined as dose-limiting toxicities (DLTs). Patients then received a flat dose of 3 × 10 7 to 1 × 10 9 KITE-585 CAR T cells in a 3+3 dose-escalation design. Patients underwent leukapheresis and subsequently received a 3-day conditioning therapy regimen (cyclophosphamide and fludarabine ). ![]() Key eligibility criteria included measurable MM and progression, defined by the International Myeloma Working Group Consensus Criteria within 60 days of the last treatment. This phase 1, multicenter, first-in-human study evaluated the safety and efficacy of KITE-585, an autologous anti-BCMA chimeric antigen receptor (CAR) T-cell therapy, in patients with relapsed/refractory MM (RRMM). B-cell maturation antigen (BCMA) is an ideal therapeutic target as it is expressed throughout the disease course with normal tissue expression limited to plasma and some B-cell lineages. The Kite Runner plays at the Helen Hayes Theatre on Broadway through October 30.Despite advances in treatment, most patients with multiple myeloma (MM) will relapse, and long-term survival remains poor. "And I'm glad they've gone in that direction. "I'm grateful to the production for doing that and it's the right thing to do," says Hosseini. Khaled Hosseini's foundation is one of the recipients. Portions of every ticket sold go to humanitarian organizations which help people in Afghanistan, as well as refugees. The Kite Runner's producers are hoping audiences have more than just an imaginative, empathetic experience at the theater. Just Amir describing the action, while the other actors appear on stage, looking up and swinging wind-making instruments "that are basically big rubber bands on a stick," says Croft, "and you spin them, and they make the sound of wind." And when Amir and Hassan fly their kite in the big kite battle of Kabul that is a centerpiece of the book – and the play – there are no kites. There are very few props – some crates, a cart and a backdrop that looks like sails. The set is simple – wooden planks, with upturned edges on either side – kind of like a skate park. It's going to take them away from that experience."Īmir Arison stars in The Kite Runner on Broadway. "What would an Afghan see when they're sitting here? You know, if the turban is wrong, the accent is wrong, and somebody's body language doesn't match that part of the world. "When I sit in that theater, I'm looking at every aspect of it with my Afghan eyes," Ghilzai explains. Ghilzai works with all elements of the production – writing, directing, acting, design – to ensure that it's authentic. So, I was best friends with Khaled's sister." And on the weekends, there were probably around 10 or 12 new immigrant families that would get together at somebody's house. "We settled in San Jose in 1980 at the exact same time as when Khaled's family had come. after the Russian occupation," says Ghilzai. I have to get spanning 26 years prepared."Īnd one of the ways Arison prepared was by working with cultural consultant Humaira Ghilzai. I have to get playing a 12-year-old prepared. "This is the Mount Kilimanjaro of acting roles that I've ever seen in my career," says Amir Arison, the actor who plays Amir on Broadway. Theater 150 Years Of Afghan History In One Theater Marathon
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